What does CZI mean?

LindaMarie76 · Apr 18, 2005

:balloons:

I did some searches on CZI followed by crystalline zinc insulin and have copied and pasted the most applicable answers

- Linda

-----------------

According to a web-site on the Mass General Department of Pharmacy/ Department of Nursing/ Critical Care, the trade name for Insulin is CZI.

http://www.massgeneral.org/pharmacy/ICU%20Guidelines/insulin.htm

------------

A medline search revealed a 1983 publication stating,

"Sulfated insulin (SI) differs radically from regular crystalline zinc insulin (CZI). To date, SI has been used mainly for the subcutaneous treatment of diabetics with resistance or local allergic reactions to CZI."

Title: Intravenous infusions of sulfated insulin normalize plasma glucose levels in pancreatectomized dogs

Authors: Nomura M, Zinman B, Bahoric A, Marliss EB, Albisser AM.

Journal: Diabetes. 1983 Sep;32(9):788-92

-------------

Regular insulin , also known as crystalline zinc insulin or unmodified insulin, is obtained for commercial uses from the pancreases of pigs and/or cattle at slaughter. The insulin is prepared by precipitating the insulin with zinc chloride, forming zinc insulin crystals. The commercially available solutions have a pH of 7 - 7.8.

http://www.elephantcare.org/Drugs/insulin.htm

------

Many types of insulin preparations have been made available,

the differences being chiefly in the duration of action. All

are injected subcutaneously, but crystalline zinc insulin, or

regular insulin, is injected intravenously when it is desired

to study either insulin sensitivity or problems relative to

the subcutaneous absoprtion of insulin.

http://www.diabetic-help.com/kANIMINS2.txt

--------

Regular human insulin is crystalline zinc insulin dissolved in a clear solution. It may be administered by any parenteral route: subcutaneous, intramuscular, or intravenous. Insulin lispro and aspart are also soluble crystalline zinc insulin, but are intended for subcutaneous injection. NPH, lente and ultralente insulins are suspensions with the regular insulin in them either complexed with protamine (NPH, Neutral Protamine Hagedorn, or isophane, meaning stoichiometric proportions) or mixed with excess amounts of zinc ions (lente and ultralente) to delay their absorption and thus extend their actions. (1,11) Insulin suspensions should not be administered intravenously.

http://www.endotext.org/diabetes/diabetes17/diabetes17.htm

--------------------

I'm working in a SICU new to me and they call insulin gtts here "CZI". They've been calling them that for so long that no one can remember what it means.
I've done a couple of searches with no luck. Can someone help me out? Just curious.