sickle cell labs

[missE]

I am taking care of a 2 yo who is diagnosed with sickle cell disease. I am still learning the patho behind what the disease entails but I am confused with some of the labs and what they entail. Any help would be great!

Neutro, total (segs + bands + metas)

Segs 77 (25-62)

Monocytes 6 (2-11)

Lymphocytes 16 (20-53)

Reticulocytes

Relative 4.2 (0.5-1.5)

Absolute 154.0 (25-75)

Imm. Fraction 0.5 (0.1-0.3)

WBC: 25.0 (5.5-15.5 k/mcL) platelets: 276 (140-440)

RBC: 3.64 (3.80-5.50 k/mcL)

Hgb 10.1 (11.0-16.0 m/dL)

Hct 29.9% (31.0-43.0)

[missE]

for anyone curious about my sickle cell child and her labs..

mt's wbcs are elevated possibly dealing with her uri and pneumonia. also, with an increase in sickled rbcs, this tends to occlude the microvascular vessels causing thromboses and pain, which is also another reason why the wbcs would elevate. rbc count is low because in sickle cell anemia the cells that are sickled shape are not able to carry the hemoglobin that is responsible for transport and exchange of oxygen like a normal rbc. hemoglobin and hematocrit levels are also low because of the direct relationship with the overall decrease in rbcs.

high segment neutrophils are related to her infectious pneumonia and viral uri. **side note: neutrophil count is elevated because of her inflation; however neutrophils are generally more likely to be elevated in bacterial infections, instead of viral infections... but this is just a generalization, not an absolute**

reticulocytes are immature rbcs. being that mts rbcs are being sickled and causing increased rbc destruction, mts body is trying to compensate for the low rbc count. this results in an increase of immature rbcs in mts system.