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How do you answer "most" and "best" questions?

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I'm about to take the NCLEX and I'm freaking out. I've been answering the kaplan q trainers. and I realized. i don't know how to answer the "best" and "most" questions like this

A charge nurse is developing the assignment for the evening shift. In a semiprivate room, Client A has neutropenia. Client B has a tracheostomy with purulent drainage and a pending culture and sensitivity (C&S). Which of the following indicates the MOST appropriate assignment?

1. Assign an experienced nurse to care for both clients in the same room.

2. Assign two nurses: one nurse for Client A and another nurse for Client B, in the same room.

3. Place Client A in a private room and assign the same nurse to care for Client A and Client B.

4. Place Client A in a private room and assign different nurses to care for Client A and Client B.

Strategy: All answers are implementation. Determine the outcome of each answer. Is it desired?

(1) should be in a private room away from roommate with infection

(2) should be in a private room away from roommate with infection

(3) should be cared for by different nurses

(4) correct–infection in a neutropenic individual may cause morbidity and fatality; place the neutropenic client in a private room; limit and screen visitors and hospital staff with potentially communicable illnesses

I got this one right but questions with "what is MOST appropriate?" or "What is Best?" how in general do we tackle them?