Need Advice on Management of Penrose Drain/Ostomy Bag

My BIL underwent radical cancer surgery two weeks ago, which included a urostomy. He also has a Penrose drain with an ostomy bag for management of drainage from one of the surgical sites. My sister is having no problems with the urostomy. However, the Penrose drain and ostomy bag is giving her fits. No matter how small she cuts the opening to accomodate the drain or how well she cleans and preps his skin or any amount of adhesive will stop it from leaking. His HH nurse even tried using a special type of adhesive tape to seal and window it. Nothing works. Within hours of changing the ostomy, it has leaked through his clothes and onto the bed. She is becoming frustrated and exhausted from constantly having to wash and change sheets, clothing, etc. Any suggestions would be appreciated.