Uptake and Distribution

charles-thor · Apr 18, 2004

Ah yes, I remember the anguish of trying to figure out the puzzle that is anesthetic uptake and distribution. I found 4 things that helped considerably:

1. Anesthetic Uptake and Action by Eger. It was written back in the sixties, and it is unfortunately out of print. I was fortunate enough to find it online at a reasonable price - some people ask an outrageous amount. It offers a very nice hydraulic model that helped me to gain a better understanding.

2. The Pharmacology of Inhaled Anesthetics again by Eger. The book is ok, but it comes with 2 DVDs that clearly explain a host of topics related to volatile agents.

3. Anesthesiology Review by Ronald Faust also has some unambiguous explanations on the topic.

4. Recording lectures in class, and then listening to them in your car is also a great way to get down some of the more difficult topics.

I hope this helps. Best of luck!

alansmith52 · Apr 18, 2004

Barsh quotes Eger all over the place only its much more readable. "Clinical Anesthesia" Paul G. Barash

chpt.... um 15 if you read the first 3 pages of chapter 15 slow. I guarntee you will understand it.

I am aussuming your talking about gas given the terminology you used.

Brenna's Dad · Apr 20, 2004

Ah, uptake and distribution, one of my favourite subjects...

Now, lets see, if your in denver will your gas be more or less soluble in blood? Does this mean you'll need more or less ET% to achieve MAC? What would your MAC of volatile agent be if you were in a unpressurized submarine 100 feet below the ocean? What would you MAC of anesthetic agent be in space? What ET% of desflurane could you achieve in space?

charles-thor · Apr 20, 2004

I'd like to make a correction to my previous post - Anesthetic Uptake and Action by Eger was first published in 1974. It's the "landmark text" as described by Barash in Chapter 15 of Clinical Anesthesia. The chapters pertaining to uptake and distribution is a must read.

alansmith52 · Apr 20, 2004

Brendas dad I love the one about mac in space. rofl. thats awsome. seems like we try to figure out the most far fetched things sometimes.

now what if the fgf outlet had been left on all weekend "in space" and what if the resevoir bag was on or off. what is our likely hood of getting carbon monoxide poisoing usuing des. and could we use an even lower flow rate.

and how bout compound A in rats on mars. how what kind of renal problems would we see then. its perplexing I cant take it anymore lol.

oh yeah what I am most concerned about are the rescent studies envloving cardio steel syndrome with Isoflurane on the international space station.. lol I kill me.