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Discussion

IV compatibility question

Maybe this is a dumb question(don't you love posts that start this way?) but if a med is compatible with NS, do you assume it is also compatible with 1/2 normal saline? I'm kind of a "by the book" girl and don't hang things together that aren't tested. But my coworker says if it's compatible with NS, it would also be with 1/2NS as it's just a different concentration. What say you?

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That's where I would call pharmacy to find out it if was okay or not, if your computer drug-lookup does not give a straight answer on it.

I would verify with pharmacy. But if there is no definitive answer I would be safe rather than sorry

  • Author

We have kings and Trissels IV compatibility lookup on our system. One doesn't list 1/2 NS at all when you search for med/fluid compatibility. The other comes up as untested when you search a med and 1/2. My coworker says this is because if it's tested with NS, it doesn't need to be tested with 1/2 but I'm not sure I buy that.

Yes ......if is is compatible with NS it is compatible with 1/2 NS. NS has 154 meq/L sodium and 154 mEq/L of chloride and 1/2 NS has 77 mEq/L of both sodium and chloride. The normal plasma level of chloride is 103/mEq/L and sodium is 140mEq/L. Since it is technically not physiologic and has more chloride and sodium than a human body needs over a few days you will see the sodium and chloride creep up and that s why you see 1/2 NS and D5 1/2 more frequently than NS unless the patient has low sodium levels or is used for a short time.

When in doubt, call pharmacy, always.

If it is compatible with NS, then it is compatible with 1/2 NS.

Yes it should be compatible. I always call pharmacy though and make sure my drugs are compatible if there is any question.

I beg to differ!!! IV Dilantin is only compatible with NSS, not 1/2 NSS. If it is not 0.9NSS there are other additives in the solution, so I do not think you can say that if one is compatible in 0.9NSS it is also compatible with 0.45NSS!! However, call pharmacy!!

OK- please remember I am studying for my Crusty Old Bat entrance exam:

It is either 0.9% NaCl ---or--- Normal Saline.

There is no such thing as 0.9NSS or 0.45NSS. Apples and oranges.

We now return you to your regularly scheduled programming.

I beg to differ!!! IV Dilantin is only compatible with NSS, not 1/2 NSS. If it is not 0.9NSS there are other additives in the solution, so I do not think you can say that if one is compatible in 0.9NSS it is also compatible with 0.45NSS!! However, call pharmacy!!

Dilantin is compatible with both NS and half-NS.

Dilantin is not compatible with dextrose containing solutions, it will crystallize. There are some meds that need to be mixed in dextrose, such as Bactrim. I took the original question as meaning can a medication run thru a line that has half saline in it, not as preparing the drug with it.

  • Guides

These links may help. There are several variables to consider including dilutent amount, pH, and infusion time.

These links explain the reasons why some medications are compatible with certain solutions and medications.

To mix or not to mix â€" compatibilities of parenteral drug solutions - Australian Prescriber

http://www.medscape.com/viewarticle/590261_3

Drug compatibility chart.

http://www.pharmacypracticenews.com/download/IV_drugs_ppn0911_WM.pdf

Drug-solution compatibility chart.

https://www.scribd.com/doc/24528278/IV-medication-Solution-Compatibility-Chart-for-nurses

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