Reconstitution Help!!!!!

I must be really thick tonight, but I haven't the foggiest idea what you're talking about.

If you have one gram of drug in a syringe and you only want 300mg of it, top off the syringe to a full 10cc with NS or sterile water, roll to mix, and you have one gram in 10cc. If you discard 7cc of it, you'll have 300 mg in the syringe in 3cc. Then add it to whatever you're going to use to give it IV.

This is a dosage calculation problem that I am trying to figure out how to work out.

according to the chart you have been provided -- you would mix the 1g vial with 10 mL and have an avg concentration of 125 mg/ml (which seems high to me since 1000 mg/10 ml = 100 mg/ml).

if you need to administer 300 mg then 300/125 = 2.4 mL

according to the chart you have been provided -- you would mix the 1g vial with 10 mL and have an avg concentration of 125 mg/ml (which seems high to me since 1000 mg/10 ml = 100 mg/ml).

if you need to administer 300 mg then 300/125 = 2.4 mL

Wouldn't it be 4.8ml since the reconstitution says for IV to add and additional 10ml NS, making total volume 20ml?

Edit ... Or would it be 12.4ml since it says (reread) an additional 10ml per dose?

i was going by the chart as written.. since it's a poorly written question as you have identified :)

I too would dilute it in 10 ml--always easier to divide/multiply by 10s/100s!

So then you'd have 1000 mg/10 ml=100 mg/ml.

100 mg/1 ml=300 mg/x ml and solve for x. ---> = 3 ml

Then add your additional 10 ml =13 ml

Yes this is the exact problem. I got the 6.3 but I added 50ml because the problem said to further dilute it with 50 ml. I'm sorry the 10ml should be 50ml. I will edit it.

Further dilute should be 50ml not 10ml.

Ok...then if 500mgs in 10 mls is 48mgs/ml to give 300mgs is 6.25mls or rounded is 6.3mls = 300mgs plus 50ml = 56.3ml of total fluid

and...if you have 125mgs/ml (even though 1gm/1000mgs in 10 mls is 100mgs/ml) and need to give 300mgs...you need 2.4mls plus 50ml = 52.4ml total fluid

Thanks Esme!

Okay. Thank you. I finally figured out how to do it. I feel so crazy. I made this harder than what it was. I got the 52.4 like you because the 1 gram IV instructions = 125mg/ml plus the 50 ml.