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Discussion

SSRI v MAOI

Can someone please explain the difference between SSRIs and MAOIs? How do these drugs function in the body?

Featured Replies

  • Experts

Not going to do all of the research for you...but here's something to get you started

SSRI: selective serotonin reuptake inhibitors.

Translation: helps prevent serotonin from being reuptook (?), resulting in higher serotonin levels

Includes fluoxetine (Prozac), setraline (Zoloft), citalopram (Celexa) and a few other common antidepressants.

MAOI: monoamine oxidase inhibitors.

Translation: inhibits monoamine oxidase.

Some older antidepressants were of this type. Noted for having severe side effects, severe and even fatal interactions with many other psych AND non-psych medications, and for requiring dietary restrictions (notably, a low-tyramine diet). So it's often prescribed as a last-resort when all else fails.

  • Experts

We are happy to help but like merriwhen says...we wont do it for you. What do you have so far? What is your understanding of these drugs?

  • Guides

Think about your physiology. What does monoamine oxidase do?

If you understand that you will understand not only the difference between the two but also why MAOIs have a large ADR profile.

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