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Discussion

PPD question

I have a quick question about PPD tests. I tried looking information about this in the drug book, but couldn't find anything. So I looked it up online and it just said it is "a purified protein derivative standard (PPD test). A solution containing certain components of the bacteria that cause TB". I guess what in asking is do you not have to look anything up for a PPD? Sorry if this is a dumb question! Thanks for any help!

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    • Experts

    "Do you not have to look anything up for a PPD"? I'm not sure I understand.

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    Say again? If you are asking, do you have to know what PPD is, what it's for, and how you know what its results are because your patient at clinical had/has one, the answer is, yes, you do, because your instructor will want to know that you know.

    If you are asking something else, please clarify for us.

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    • Author

    Yes, I knew what it was for, and what reaction to look for, where to give it, and everything else, but didn't know exactly what the solution was or anything else about it.So do you just go by this general info, because I couldn't find anything when I looked it up...like what the availability is.

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    • Experts

    What do you mean by...the availability.....Purified Protien Derivative It is also known as the Mantoux test - Wikipedia, the free encyclopedia and a Tine test - Wikipedia, the free encyclopedia

    Diagnostic Antigen For Intradermal Injection Only

    DESCRIPTION

    Aplisol (tuberculin PPD, diluted) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The solution is stabilized with polysorbate (Tween) 80, buffered with potassium and sodium phosphates and contains approximately 0.35% phenol as a preservative.

    This product is ready for immediate use without further dilution.

    The purified protein fraction is isolated from culture media filtrates of a human strain of Mycobacterium tuberculosis by the method of F.B. Seibert.1,2 Tuberculin PPD, diluted, is prepared from Tuberculin PPD Powder Master Lot 154616 which is clinically bioequivalent in potency to the standard PPD-S* (5 TU** per 0.1mL) of the U.S. Public Health Service, National Centers for Disease Control. This product is made from a single master lot (No. 154616) to eliminate lot to lot variation inherent in manufacturing.

    The potency of each lot of tuberculin PPD, diluted is determined in sensitized guinea pigs.

    APLISOL (TUBERCULIN PURIFIED PROTEIN DERIVATIVE) INJECTION [JHP PHARMACEUTICALS LLC]

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    Since it is not a drug you do not need to know how it's available (I am guessing that you mean like Amoxicillin comes in 125mg/5mL, 500mg/5mL and 875mg/5mL suspension, 500mg tablets, 875mg capsules, etc.)

    It is a test. The same way you don't need to know drug details about a rapid strep test or culture medium.

    This is why you won't find any information about it in a drug handbook or the PDR, it's not classified as a drug but as a biological for challenge testing/evaluation.

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    • Experts
    Since it is not a drug you do not need to know how it's available (I am guessing that you mean like Amoxicillin comes in 125mg/5mL, 500mg/5mL and 875mg/5mL suspension, 500mg tablets, 875mg capsules, etc.)

    It is a test. The same way you don't need to know drug details about a rapid strep test or culture medium.

    This is why you won't find any information about it in a drug handbook or the PDR, it's not classified as a drug but as a biological for challenge testing/evaluation.

    Actually I found it...
    .DESCRIPTION

    Aplisol (tuberculin PPD, diluted) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The solution is stabilized with polysorbate (Tween) 80, buffered with potassium and sodium phosphates and contains approximately 0.35% phenol as a preservative.

    This product is ready for immediate use without further dilution.

    The purified protein fraction is isolated from culture media filtrates of a human strain of Mycobacterium tuberculosis by the method of F.B. Seibert.1,2 Tuberculin PPD, diluted, is prepared from Tuberculin PPD Powder Master Lot 154616 which is clinically bioequivalent in potency to the standard PPD-S* (5 TU** per 0.1mL) of the U.S. Public Health Service, National Centers for Disease Control. This product is made from a single master lot (No. 154616) to eliminate lot to lot variation inherent in manufacturing.

    HOW SUPPLIED

    Tuberculin PPD-Aplisol bioequivalent to 5 US units (TU) PPD-S per test dose (0.1 mL) is available in the following presentations:

    NDC 42023-104-01 (Bio. 1525)

    1 mL (10 tests) – multiple dose vial

    NDC 42023-104-05 (Bio.1607)

    5 mL (50 tests) – multiple dose vial

    This product is ready for use without further dilution.

    .APLISOL (TUBERCULIN PURIFIED PROTEIN DERIVATIVE) INJECTION [JHP PHARMACEUTICALS LLC]
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    Right, but all biological substances are required to provide that information, it's just not included in drug books. The information is available just not in the typical locations one finds therapeutic drug information.

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    • Experts

    I agree and as a student they may not know this.....:)

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