Tpa dosage calculation

have not seen any problems like this. usually, this is a critical situation and the doctors actually write the first dose out and it is started in the er and continued in the ccu or icu. i have specific dosage information on this drug in my copy of 2007 intravenous medications, 23rd edition, by betty l. gahart and adrienne r. nazareno if you would like me to print it here for you. otherwise i have two websites with information:

• http://www.drugs.com/ppa/alteplase-recombinant.html - professional information on recombinant alteplase (tpa-tissue plasminogen activator)
  
• http://www.emedicine.com/emerg/topic831.htm - thrombolytic therapy

these dosage calculations are similar to the ones worked out in this thread where you have to consider the patients weight in kg, a certain mg and a certain length of time of delivery (in this post it is 24 hours, but it can easily be changed to 30 minutes or 2 minutes as in the case with calculations involving alteplase): https://allnurses.com/forums/f205/please-help-peds-math-322574.html

a man who has had an acute mi has been ordered to have an infusion of tpa started. 100mg of tpa is to be diluted and mixed in 100cc of normal saline and infused through a metriset on a pump that has been piggybacked into the patient's main iv line. the orders for infusion are as follows: an initial infusion of 15 mg is to be given over 2 minutes followed by the next 50 mg to be infused over the next 30 minutes and finally the last 35 mg is to be infused over the final 60 minutes. calculate the correct infusion rates.