Propofol and LR solution

A single invitro observation that doesn't come close to an actual clinical setting? No doubt someone with something to prove would make an issue out of this observational science fair project but there's a reason we've been using propofol with LR for many decades without any problem at all. And how would you notice precipitate with propofol in normal clinical practice, anyway?

offlabel said:

A single invitro observation that doesn't come close to an actual clinical setting? No doubt someone with something to prove would make an issue out of this observational science fair project but there's a reason we've been using propofol with LR for many decades without any problem at all. And how would you notice precipitate with propofol in normal clinical practice, anyway?

Those are all fair points! I have never witnessed precipitate form with propofol in my practice. Do you mean in that it is a opaque white emulsion, precipitation would be hard to visualize? 

Kate96 said:

Those are all fair points! I have never witnessed precipitate form with propofol in my practice. Do you mean in that it is a opaque white emulsion, precipitation would be hard to visualize? 

yes

Kate96 said:

Those are all fair points! I have never witnessed precipitate form with propofol in my practice. Do you mean in that it is a opaque white emulsion, precipitation would be hard to visualize? 

No, LR with Propofol is not an issue.  I often mixed Propofol in a bag of LR to use as sedation in the OR .  I also have pushed thousands of boluses and I'm looking closely at the injection site and have never seen a precipitate.  If there were a precipitate, it would affect the time unconsciousness occurs and haven't noticed any longer times for the drug to take effect.  After the devasting  hurricane in Puerto Rico, American manufactured Propofol in the US was so affected that we were forced to buy it from Europe and their formulation was a bit different from ours.  We noticed longer times for effect in most patients.  The study you gave us was performed in Europe so maybe that is affecting their results.  Also, even though studies are published with "NIH" on the headline doesn't mean that they are peer reviewed and should be taken with a grain of salt.  I didn't find this out until Covid when I saw a study with an n of 9 and wondered how it ever got published!