Hello, I've had a master's degree in Nursing Informatics (NI) since 2000. I guess you could say, I'm one of those people who came into this field with only bedside nursing experience and a degree in NI. In my 11 years in this field, I've seen lots of people hired with and without an advanced degree, but in my opinion, an advanced degree in nursing is always desirable. personally, I have never worked in a hospital IT department, but went right into the vendor world. At the time, I was a desirable candidate because of my clinical background combined with an advanced degree, albeit, no real IT experience. As one of the posts above mentions, I did start with an entry level position, but quickly worked my way through various positions and am now a senior level marketing consultant and work strictly from a home office with occassional travel to our corporate office. I have actually been a remote-based employee for the last 8 years, but did some extensive travel early on in my NI career. In my experience, you can be hired into the NI field without IT experience, but these positions are definitely becoming more competitive then they were ten years ago when I started in this field. If you can gain the experience while you're working on your degree, even better! Best of luck to you.