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Discussion

Halothane induced malignant hyperthermia

I am needing some help with a class for my bachelor degree in nursing and seeking some expertise from CRNA's out there. We have a case study about halothane and Malignant Hyperthermia and are having a hard time answering it. Part one is self-explanatory, however the rest is too in depth and we are unable to determine the exact effects of halothane. Any advice? Here is the link:

http://www.sciencecases.org/teeth/teeth.asp

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I'd suggest going to mhaus.org could be helpful, are your other group members stumped as well?

This is a good website:

http://www.anes.ucla.edu/dept/mh.html

Halothane is one of many inhalational agents that trigger MH. All the inhalational agents effect the same cellular responses to trigger MH. So just looking for "Halothane" in your searches would be limiting.

i agree - the mhaus site will be your best option..but halothane like all triggers of MH cause an inappropriate release of calcium from the sarcoplasmic reticulum - specifically the ryanodine receptor is believed to be the problem site - good luck.

I agree, these are great sites for MH information. Did you know that farmers gas all their pigs at slaughter with halothane? I read that since malignant hyperthermia in pigs makes their meat inedible, farmers expose all new piglets to halothane to make sure they will not develop MH. That way, they limit the expense they will incur by raising a pig until the time of slaughter only to find that it develops MH and is a total loss. I'll have to see if I can find that source. Good luck in your project.

Z

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