Take the job or not

I am having some what of a dilemma. I am graduating soon and have been doing the normal job search since earlier this year. However, I have had some offers recently for jobs in the area I live now, but I do not know if I should take any of them. My real goal is to apply to this nurse residency program but they only have two cohorts a year like in jun and jan. And since when I am graduating and time constraints I cannot do the jun cohort. My goal would be to be part of the jan because they will take you as long as you do not have six months experience at the time you are applying for the program (august-sept). Would it would be rude to take a job around here knowing that I could possibly be leaving the job if I was accepted at another place. I just hate to know the fact that they would have to spend time orienting me and all of that and then I leave because of another opportunity. However, I hate to just sit around for a few months possibly doing nothing, especially if getting accepted did not work out. Any opinions about this situation would be very helpful...