Safe dose

[msteez]

How do you determine safe dose ranges for cefotaxime 270 mg via IV piggyback.

Sterile water for injection 5.4 mL concentration = 50 mg/mL, Q8H?

Infant weights 5kg and is 30 days old.

I found different safe dose ranges, but I'm not sure which one to use.

[Esme12, ASN, BSN, RN]

you look it up. CEFOTAXIME (CLAFORAN ®) -Â Intravenous (IV) Dilution

Neonates, Infants, and Children: The following dosage schedule is recommended:

Neonates (birth to 1 month):

0–1 week of age 50 mg/kg per dose every 12 hours IV

1–4 weeks of age 50 mg/kg per dose every 8 hours IV

It is not necessary to differentiate between premature and normal-gestational age infants.

Infants and Children (1 month to 12 years):

For body weights less than 50 kg, the recommended daily dose is 50 to 180 mg/kg IM or IV body weight divided into four to six equal doses. The higher dosages should be used for more severe or serious infections, including meningitis.

In your problem they say 4 weeks and no one month so I am going to say they want the dosage of

1–4 weeks of age 50 mg/kg per dose every 8 hours IV

in real life if pharmacy did not question it....I would call the MD and clarify how many mg/kg they want given.

So at 50mg/kg your dosage is......5kg x 50mg=____ for one dose.

It is being given Q8H. ____mg x 3(doses) = _____mg/24 hours.

The dose being given is cefotaxime 270 mg x 3 (every eight hours) so the total dosage ordered in 24 hours is....270mg x 3 = ______mg/24 hours.