DJD, I really think you should go for it. You have nothing to lose. I recently turned 50 and am just starting nursing school after finally finishing my prerequisites. I was a cross country truck driver in my previous career. I tired of living on the road and through research (like you did) found out health care jobs have the best future, security, etc. I wouldn't worry about the physical aspects. My back is kind of messed up and my hearing is shot, but I haven't really seen that as holding me back yet. This is just an observation and not a harsh judgement or anything, but so far the majority of my nursing instructors have been overweight women. So I have not seen anything yet which requires superior fitness. The fact that you like working with women is also a big plus. Good luck and let us know what happens.