hi i'm a renal nurse from australia.UF profiling mainly for the way you want to take the fluid off. For instance, you might be planning for 2 Kg off over 4 hours , you can decide that 2L off in many ways , firstly in a steady rate 500ml/hr which means no profile. i believe you are using fresius machine, proflie 1, 3, 5 0r 6. So when you use profile you are giving time for good vascular refill. there is no point in using profile if the serum albumin level is lower than 32mmol/l