If the PICC is designed with clamps, it probably lacks an integral PASV (pressure activated safety valve) and would need to be clamped while changing the injection caps. If the PICC does not have clamps, clamping is probably not necessary due to the presence of an integral PASV. However, check your PICC manufacturers recommendations and your institutional policy. For a good discussion, see http://jcleahy.blogspot.com/2010/11/picc-lines-purpose-use-and-care.html