Hi! May I suggest that you use a cotton cloth (or any piece of cloth) wrapped around the head of the ampule. Grabbing the ampule from the head, firmly position your thumb towards the dot / line while your pointing finger is parallel to the ampule's neck. Twist it and you will hear a breaking or 'popping' sound. This technique helps to avoid puncture and breaking the ampule. Though based on experience, there are really some ampules (like vitamin c amps) that are very fragile. This technique helps lessen the risk of injury. Take care! Hope this helps.