A stick is always cause for concern and anxiety but the best salve is accurate information. I manage all BBP (bloodborne pathogen) exposures for our company and am surprised that you are taking "meds" for this stick. Using our "risk assessment" you would not be at risk because the needle was not a "contaminated" needle. Also, the stick was not a deep puncture and was not from a "body fluid filled device" (it was filled with medications). The only risk factor is that the patient is HIV +, but it sounds like no body fluid contact occurred. It might help to remember that HIV is not a very hardy virus and it takes a fair amount of exposure for infection to occur, unless you are immunocompromised. I would guess that your physician opted to recommend prophylaxis for risk management purposes as much as anything else, but the therapy is not without it's own issues! The CDC website has good info, as does APIC. I hope this will help you cope with all the fear, but I would not be too worried this time. You were smart to report it and follow up labs will let you get closure on this over time. Hang in there!