I'm not an RN, yet.... but I do have Crohn's. I have had six Remicade infusions over the past two years and have never had any severe reactions. The only thing I've noticed is that approximately 12-24 hrs after the infusion, I experience flu-like symptoms: moderate body aches, low grade fever and just really feel tired. This usually lasts 4 or 5 days, then I'm fine. I have been on Imuran for five years and have had no problems. I would be happy to answer any questions anyone has.