I know this is an old thread, but was looking for some info on TPN and what can be run with it. I work in a step down ICU and had a patient with no PICC because of too much scar tissue (it was attempted twice, settled with a single lumen hickman port) and she also had a peripheral wrist 20 g. She was gettig TPN through the hickman and Vanco and zosyn through the PIV. Well now K+ is low, so I've got an order for 2 bags of potassium (no lidocaine or anything else). Ran that with saline in the PIV and blew the vein (shocking). Attempted to get another PIV and blew the vein ? So I recruited help from the US machine and some seasoned nurses who also informed me that TPN has potassium in it so I can run the potassium into the hickman port and run the TPN at the Y-site. I was ALSO taught that TPN should have a dedicated line but I was desparate and it worked well. We change out all the tubing and brand new tpn every 24 hours.