Need help with Thesis

[acestaniel]

First off I would like to say hello to all the moderators and members of allnurses.com I am a 3rd year nursing student from the Philippines and I registered here because I need some technical help with our thesis. Me and my partners are planning to do a research on wound healing using white mice. The focus of our study is on common topical agents used in wound healing against the traditional home remedies used by people belonging to the lower income bracket. We want to know first off why white mice are usually the ones used in clinical trials, next off is what possible variables do we need to use. Please bear with us, this is our first time to write a thesis and our Research teacher is not of any help to us. Thank you in advance for all the help you can provide :)

[VickyRN, MSN, DNP, RN]

First off I would like to say hello to all the moderators and members of allnurses.com I am a 3rd year nursing student from the Philippines and I registered here because I need some technical help with our thesis. Me and my partners are planning to do a research on wound healing using white mice. The focus of our study is on common topical agents used in wound healing against the traditional home remedies used by people belonging to the lower income bracket. We want to know first off why white mice are usually the ones used in clinical trials, next off is what possible variables do we need to use. Please bear with us, this is our first time to write a thesis and our Research teacher is not of any help to us. Thank you in advance for all the help you can provide :)

Welcome to the Nursing Student Assistance Forum :balloons: Others may be able to offer other insights, but this is an excellent article on the use of mice in research:

http://www.vetmed.ucdavis.edu/Animal_Alternatives/cancer.htm

Mice DNA is surprising similar to human DNA. Mice are small, social animals and many can be housed in a small space (laboratory). White mice have less genetic variation, so more control over confounding variables. Several generations of mice can be bred in a relatively short time, enabling the researcher to compare effects of treatment quickly over many generations.

[acestaniel]

we cited elevated temperature as one of our nursing variables in our thesis, is there a way to measure a mice's temp? what is their normal temp by the way? thnx for the reply by the way....

on an unrelated note, which is better for MS, saunders or lippincott?

[aka]

Basically, what clinical trial are you trying to do?

If you're into something that needs sacrificing the subjects to attain your results, ethically it would be proper to do it to the mice who are in fact laboratory specimens, as compared to humans. You have to check on the ethical way of killing the mice though. I know that you have to perform cervical dislocation as a procedure and another one. Just check on the procedures.

If you're testing a drug for efficacy to obtain either its pharmacokinetics and pharmacodynamics, i guess, you're into something that wouldn't require humans as a primary test subject, ethical wise. There are specific levels on testing a drug and you might get that from drug companies.

If from the computation of required numbers to treat you obtain a high population, time would not be on your side if you do random sampling or stratification would not be feasible and the multiplication rate of the mice would definitely help you out.

I do hope i helped you out on this one.