aka

Basically, what clinical trial are you trying to do? If you're into something that needs sacrificing the subjects to attain your results, ethically it would be proper to do it to the mice who are in fact laboratory specimens, as compared to humans. You have to check on the ethical way of killing the mice though. I know that you have to perform cervical dislocation as a procedure and another one. Just check on the procedures. If you're testing a drug for efficacy to obtain either its pharmacokinetics and pharmacodynamics, i guess, you're into something that wouldn't require humans as a primary test subject, ethical wise. There are specific levels on testing a drug and you might get that from drug companies. If from the computation of required numbers to treat you obtain a high population, time would not be on your side if you do random sampling or stratification would not be feasible and the multiplication rate of the mice would definitely help you out. I do hope i helped you out on this one.