Magnesium sulfate

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Hello could some one tell me some of the signs seen when the magnesium sulfate (preclamsia) is within the therapeutic range. I know there is a fine line between toxicity and therapeutic range Thanks

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Specializes in MPCU.

Altman, D., Carroli, G., Duley, L., Farrell, B., Moodley, J., Neilson, J., et al. (2002). Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial. Lancet, 359, 1877-90.

Ascarelli, M. H., Johnson, V., McCreary, H., Cushman, J., May, W. L., & Martin, J. N. (2005). Postpartum preeclampsia management with furosemide: a randomized clinical trial. Obstetrics and gynecology, 105, 29-33.

Belfort, M. A., Anthony, J., Saade, G. R., & Allen, J. C. (2003). A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia. The New England journal of medicine, 348, 304-11.

Blackwell, S. C., Hallak, M., Hassan, S. S., Berry, S. M., Russell, E., & Sorokin, Y. (2001). The effects of intrapartum magnesium sulfate therapy on fetal serum interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha at delivery: a randomized, placebo-controlled trial. American journal of obstetrics and gynecology, 184, 1320-3; discussion 1323-4.

Ehrenberg, H. M., & Mercer, B. M. (2006). Abbreviated postpartum magnesium sulfate therapy for women with mild preeclampsia: a randomized controlled trial. Obstetrics and gynecology, 108, 833-8.

Livingston, J. C., Livingston, L. W., Ramsey, R., Mabie, B. C., & Sibai, B. M. (2003). Magnesium sulfate in women with mild preeclampsia: a randomized controlled trial. Obstetrics and gynecology, 101, 217-20.

Lumbiganon, P., Gülmezoglu, A. M., Piaggio, G., Langer, A., & Grimshaw, J. (2007). Magnesium sulfate is not used for pre-eclampsia and eclampsia in Mexico and Thailand as much as it should be. Bulletin of the World Health Organization, 85, 763-7.

Schauf, B., Becker, S., Abele, H., Klever, T., Wallwiener, D., & Aydeniz, B. (2005). Effect of magnesium on red blood cell deformability in pregnancy. Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy, 24, 17-27.

Scott, J. R. (2003). Magnesium sulfate for mild preeclampsia. Obstetrics and gynecology, 101, 213.

Simon, J., Gray, A., & Duley, L. (2006). Cost-effectiveness of prophylactic magnesium sulphate for 9996 women with pre-eclampsia from 33 countries: economic evaluation of the Magpie Trial. BJOG : an international journal of obstetrics and gynaecology, 113, 144-51.

The Magpie Trial: a randomised trial comparing magnesium sulphate with placebo for pre-eclampsia. Outcome for children at 18 months. (2007a). BJOG : an international journal of obstetrics and gynaecology, 114, 289-99.

The Magpie Trial: a randomised trial comparing magnesium sulphate with placebo for pre-eclampsia. Outcome for women at 2 years. (2007b). BJOG : an international journal of obstetrics and gynaecology, 114, 300-9.

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Specializes in Perinatal, Education.

Thank you VERY much Woodenpug. I knew there was a lot of new literature out there about Mag but have seen little in the way of change in MD practice.

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Specializes in MPCU.

This link is to an article which explains the significance of the magpie trial and the reason for little change in MD practice. The article was written before the trials.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1116139

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