With HFOV, think of it as "CPAP with a wiggle." The "CPAP" is given with the MAP and the "wiggle" is given with the AMPs and Hz. MAP (and of course, FiO2) controls oxygenation. Increase the MAP to increase oxygenation. Amplitude (aka. DeltaP or Power) and Hz (frequency) control the amount of CO2 blown off from the lungs. To help blow off CO2, increase the AMPs or decrease the Hz. One Hz equals 60 breaths per minutes, so a Hz of 10 would be equivalent to 600 breaths per minute. The reason that decreasing Hz would help lower the CO2 is because #1 more time for exhalation and #2 more tidal volume is given to the infant. Hope this helps! Check out this link for an excellent explanation of HFOV given by a brilliant child with Tay-Sachs disease. http://www.youtube.com/watch?v=s8C7StisDFM