Analgesics are given either rectally or via IV route. Acetaminophen is used instead of aspirin or nonsteroidal antiinflammatory drugs as these affect platelet aggregation and can contribute to bleeding. In addition, aspirin is avoided as it has been linked to Reye syndrome. This is what my rationale said for my NCLEX question bank. Isn't tyenol and acetaminophen the same thing? I am so confused over the OTC analgesics names/generic names and what there contraindications are. I know NSAIDS are not to be used in heart failure, but which drugs classify as NSAIDS? Thanks everyone.