thank you for your post no reason, when i am ask them, they said there is a different protocol references and the concentration should be between 1mg - 4mg /ml for the calculation i am using this formula ( dose rate X total volume) =rate ml/hr rituximab dose for the example up this is the answer: 50mg x 560ml = 37.3 ml/hr for 30 minutes 750mg increase the rate to 100mg if no reaction 100mgX560ml = 74.6ml /hr 750mg and you will continue increasing rate until 400mg/hr this is the maximum rate. The 90-minute RITUXAN infusion in cycle 2 -6 20% of the total dose over the first 30 minutes 350ml _ 20% = 70ml you will give it over 30 minutes the rate should be 140ml/hr 80% of the total dose over the following 60 minutes 350ml _ 80% = 280 ml the rate over 60 minutes is 280ml/hr i need some one to confirm if this is right calculation !!!!