Dear all, I am working on handling instructions for prefilled propofol syringes and I am stuck with a question only an experienced user may know. Therefore, I dare asking you. Maybe you can help me answering the two short questions below. I am trying to find out how the following situation is handled in clinical practice: When propofol is given as a bolus, will a syringe with a scale in 0.5 ml increments be sufficient to measure the intended size of a bolus or would a syringe with smaller increments, e.g. 0.2 ml, be necessary? My second question concerns the areas of use for prefilled syringes with 10, 20 and 50 ml. I understand the small ones are for induction and procedural sedation, the large one for anaesthesia and long term sedation. Did I miss anything? Thank you very much for your kind help Sylvie