Is it safe to administer chemotherapy and transfuse PRBC/blood products via 2 lumen PICC line? I was caring for a patient one night who was on a continuous cytarabine infusion x 7 days, and was having to receive PRBC/plts fairly frequently. Additional peripheral line was established on opposite arm to allow for IV antibiotics/transfusions. I transfused plts on the peripheral line since "you can not run anything with chemo infusion" (as I was taught by my preceptor). However, when I returned the next night, the AM shift nurse had both the chemo and PRBC infusion going to that 2lumen PICC, and IV vanco on the peripheral. His response was that "well, _____ (clinical supervisor) said it was okay" because one of the oncology MDs had once told her that it was fine to do so. I asked other nurses on the unit (med/surg/oncology) and they were not sure. I attended a chemo provider course and was "checked off" for chemo administration by the senior "chemo nurses" before I was able to start chemo administration but that was it, and I'm pretty new to the whole oncology/chemo world. Any info would be greatly appreciated.