I have had multiple kidney stones each and every year for more than thirty years. I was one of the first female recipients of Flomax (at the time there was no generic available). My health insurance company refused to pay for this initially, however my doctor insisted that it was necessary and it did, in fact, help me pass kidney stones. I still use this today when I have stones that are difficult to pass. I started taking this when I was in my early twenties and I have never had a negative reaction. I does cause some drowsiness but the benefit is worth the minor effects.