Clinical Research changes constantly. It's very dry right now generally w/ changes at federal level and in pharma-world, and they are trying to figure out ways to not pay nurses' salaries. This ebbs and flows, but its a low point now. If you work for industry they will work you till you're skin & bones--I wouldn't recommend it. If you work for an academic center, your hours will be more sensible, and your benefits good. You'll have colleagues if you're good at networking. You will be expected to play a zillion roles at one time, which many nurses are very good at. (it wore me out). if you want more schooling, I'd recommend a general "leadership" type general MSN (rather than a research-specific one). You can always learn research on the side, or get a research certificate if you really really want it.