Taking care of a pt for the past couple days and want some advice on what could've been done differently or not, for the sake of learning purposes.... This pt had a TBI, was having pupillary changes 3rd day hospitalized and started on hypothermia protocol...was on it for a week, managed ICP with mannitol q6, 3% drip, and 23% PRN...a week later a crani/bone flap was done to help with the ICP...next day, hypothermia D/C'd, nimbex off, slowly rewarming pt at 7am, cough/gag intact, pt partially blinking, spont breathes, 6pm pt at goal temp. Next day, 7am pupillary changes more and more frequent, MRI ordered, pt starts deteriorating fast.....unable to use previous drips as sodium was critically high. End of shift patient herniates, pupils fixed and dilated, all reflexes lost.