Sedation holidays should be a part of the routine assessment at the start of each shift. Generally I decrease the amount of sedation my patient is currently receiving in an effort to assess his or her ability to follow commands, orientation, compare muscle strength, etc. I never just stop the sedation, I gradually decrease it until the patient begins to respond to my voice. I find they become less agitated and usually I'm able to completely stop the sedation this way. My facility policy is for the nurse to perform a sedation holiday once daily. It is typically done in the morning during change of shift throughout physician rounds (if the patient can tolerate it). The sedation holiday is considered a part of ventilator weaning thus it's relationship to VAP prevention.