Recommended dilution for Zofran is 1:2. 50ml bag seems excessive. I work in pediatric oncology/BMT where you can't afford to use large amounts of fluid. So we usually dilute it in a 10ml syringe. Zofran can be pushed. However if its given around the clock, we run it over 15min which is the intermittent infusion recommendation. Someone mentioned Reglan. Low dose Reglan (0.1mg/kg) can be given without Benadryl. However if you are using 1mg/kg, should be mixed with equal amount Benadryl to prevent extra pyramidal reaction. And Benadryl shouldn't be pushed in general.