kwagne11

I have a question from my graduate pharmacology class and have been trying, and trying to find an answer! If anyone has any help or insight it would be greatly appreciated! Ques. A comatose patient is admitted to the Emergency Department four hours after taking an overdose of phenobarbital. The plasma level of the drug at the time of admission is 100mg/L, and the apparent volume of distribution, half life, and clearance of phenobarbital are 35L, 4 days, and 6.1L/day. Respectively. The ingested dose was approximately: a.) 1g, b.) 3.5g, c.) 6.1g, d.) 40g, e.) 70g, f.) 110g I was looking for a dose/plasma ratio or some type of formula and have been unsuccessful!