I just completed the first week, so I don't have much experience, but I do know that it is mentally draining and requires TONS of reading. We were just assigned a 200 page reading for Pharm to be completed before next Wednesday. The upperclassmen are seriously lifesavers, everyone is so helpful and really interested in seeing you succeed. As for the professors, they are great people, but are not there to hold your hand, like you may have been used to with prereqs. They are not there to make sure you come to class everyday or hounding you to turn in assignments, so it's really up to you and your determination to take charge of this experience and excel. Make friends with as many people as you can, and lean on each other to make sure that everything is getting completed on time and concepts are really being understood. Good luck to you!