Wow. This is perfect! Thank you so much for the reference. I will look at our hospital library to see if I can get the article for free. The JAVA wants $10 for the one article which it is worth to me if my Mom's provider would do Cathflo in the home! I know Cathflo is safe- it's a naturally occuring enzyme in our bodies but changing the policies of a huge institution such as Kaiser is another story! Again, thanks a million. I searched google last night and found a lot of articles about PWO and Activase but none specific to the home care setting!