I just had a patient who had an amiodarone drip in a PIV. I switched the IV site to the opposite arm due to redness at the site, and pain and edema in the area of the lower arm above and around the site. In less than 12 hours, the new site has started to have similar symptoms so I have switched the amio gtt to a 3rd site. There should be some more literature on this because it's obvious from the comments that this issue is not rare.