We've tried using Precedex when we're short on propofol, but the docotors don't realize that Precedex is an adjunct to propofol/other sedation methods, it cannot just be started on its own. The drug company specifically draws out the appropriate way to add Precedex for sedation and wean off propofol, but I have yet to see it ordered that way. I've also had issues with using midazolam drips it seems you still need to add additional fentanyl to better comfort the patient.