syke

Thanks for your answer, unfortunately I can't really elaborate, I'm a medical researcher looking at the implications of head impact trauma, such as those found in car crashes, on the GIT due to the gut brain axis. Though, there are several papers on pubmed that look on animal models of stress/trauma and their effect on GI permeability and pathology.

Hi, I'm just curious about patients who have received impact trauma, specifically to the frontal cortex (as often seen in car crashes). Its been reported that recovering head impact trauma patients may suffer from intestinal difficulties in the reabsorption of bile, initially a mass emptying of goblets cells leading to intestinal barrier dysfunction and permeability factors. The suggstion is that these factors can lead to sepsis due to opportunistic or other pathogenic infections. Do patients typically have gasterointestinal difficulties that may be observable macroscopically, for instance in stool make up and content. Are there any particular blood markers that one would expect in patients who have undergone head impact trauma? Thanks.