The pain assiocatiated with an IV stick is from the nerves at skin level, unless you happen to hit a nerve that may be close to the outside of the vien since nerves, arteries and viens tend to be in bundles. So, not really. The pressure can be felt. On a missed IV attempt, you are in the connective tissue, and closer to the nerves, that is why they can be more painful than a succesful stick. Another point, the size of the needle does not matter. A 22ga causes the same pain as a 16ga, since the nerve endings are not as finely differeniated as they are at the finger tips.