You stated that each time the wounds are debrided they get worse. This can be a sign that the patient doesn't have good blood flow to the area. Without good blood flow, no wound treatment will work. I would check with his physician to see if he has sufficient arterial flow. If he doesn't, then he needs to be revascularized. Another sign of infection is copious amounts of drainage. Has the wound been cultured to check for infection. I have used mesalt on many patients that their wounds were had slough and also on wounds that had healthy wound beds, both types of wounds did experience minimal pain with mesalt. Moistening the mesalt prior to placing it into the wound bed can decrease the pain, but if patient still experiences severe pain and you are unable to manage it appropriately then a different dressing needs to be used. Pain is our fifth vital sign and we cannot ignore it.