I have never had any issues with reglan, which we give often in the ER. And in 5 years I have had one patient not be able to "sit still" and felt agitated after getting compazine which was diluted in 10cc and given over 2 mins at least. One other person had those symptoms, and that is when I had received it! it sucked, I wanted to jump out of my skin, but felt so tired at the same time! anyway,dont jeopardize your license. but dont worry that your pt will have that reaction, because ive given both drugs hundreds of times. many more issues with decadron IVP, and benadryl IVP.