I never really understood this and I don't believe it. I have taken a picc line that was a demo and hooked a 3cc syringe to it and pushed. Since there is not much fluid to push, very little pressure is generated. BUT... when you hook a 10cc syringe to it and push... There is a lot more fluid and a bigger piston and you can generate a lot more pressure over a longer period of time and it comes flying out the end of it. I have watched nurses push extremely hard and fast on that 10cc syringe. I can't imagine what a 30 or 60cc syringe can generate. That is a very large piston with a lot of volume trying to squeeze fluid through a very small hole. I do use 10cc syringes with picc lines, but I press very slowly and evenly. I would not hesitate to use any kind of syringe with a picc line, just don't go crazy on pressing the plunger.