My hardest pre-req was Micro for sure! As for nursing, the hardest course so far was Maternity. Although I absolutely loved clinicals and loved the professor I had, it was TOUGH. My school splits Maternity & Peds in 1 semester, so I finished Maternity in 7 weeks, which mean an exam every other week! Really tough, but I made it. Not looking forward to Med-Surg 1 next semester!