I am a 4th year nursing student. Currently I am doing my preceptorship at ICU. Here is the patient's profile (has been modified for patient's confidentiality): Patient X, male, 50 years old. Dx: Hypertensive Emergency Medical history: GIST (GI Stromal Tumor), metastatic to liver, lungs, and spine. Surgery in 2004 &2005. Pt. used morphine for pain control at home. Patient was on PO chemo trial since last month. One week ago, pt was brought to ER for increased BP (200/110), increased HR, altered LOC. Patient C/O loss of vision and increasingly confused during waiting period at ER. MRI revealed bilateral parietal and occipital edema. Pt was intubated and transferred to ICU for BP control. At my shift: Pt was extubated 5 days ago. Night nurse reported that pt. had an episode of coughingà BradyàSaO2 dropped to 86%, was put on 100% O2, SaO2 returned to 96% after. ABG showed PCO2=63. Pt was on 33% FiO2 when we start our shift. We drew another ABG 0730: PH=7.43, PCO2=52, PO2=80, HCO3=35. SaO2=96%. During assessment, pt is not fully oriented, but follows commands, moving all ext., no pain. Pt is only on Diludid infusion for pain control, no sedation. Pt's BP remains stable (MAP at 90's) while sleeping. But once pt is awake, he is agitated, tries to get off from bed, MAP shoot to 130 to 140, SaO2 drops to low 90's. We tried to re-orient the pt, get him on the chair, relaxation music, distraction..., but nothing worked. Pt. has to be restrained to keep him pulling all the lines and tubes. Family said he is never an aggressive person. During our shift, we had to give him a lot of Propofol and versed bolus to calm him. My questions: What are the possible causes for the agitation? My interpretation of the ABG: Metabolic alkalosis with respiratory acidosis (I know the PH is fine, but the numbers are abnormal, right?) . But which one is compensating which one? Are the kidneys trying to compensate the respiratory acidosis? Thank you for reading this long posting. I am just curious to know:heartbeat