The exact way that I do this is..... The TPN runs thru the medial port (triple lumen)... It is time to change the tpn anyways so I just clamp port and discard tpn. I then flush medial port with 10 ml of ns. I go ahead and flush each of the 2 unused ports with 10 ml of ns each. I then go ahead and do my dressing change, visit etc. About 20 minutes later I waste 10 ml from the distal port then draw my blood. Pt is not recieving any other fluids... I would understand the glucose being messed up... but the H&H?? I have done this hundreds of times with central lines... I just was not sure if a picc line would be different?? His hgb was 7 last wed, saw md on Fri ... 11 on Monday and 5 today?!?!