The pyxis can definitely be wrong. It is not beyond a pharmacist or pharmacy tech to make a mistake. I have known of our pharmacy miscounting and stocking drawers with incorrect meds/doses. Our pyxis has a profile for each patient. I once got a scheduled xanax 0.25 out for one of my patients, went to give it and realized that I had a xanax 1mg. The only drawer that opened when I selected the med. was the drawer with what was supposed to be only xanax 0.25mg. I went to return the med. and find the problem. The drawer contained both 1mg and 0.25mg tabs. Although this was the pharmacist's mistake, had I trusted the pyxis and given the med. the error would have been on me.