The central location of the tip has never been the issue as far as I knew. It was whether the infusions being administered could be delivered that way. There are of course many that I would not such as high doses of Potassium, Ampho, Acyclovir etc... Vanco (at least not without a dial-aflow), but Zosyn, NS, etc can. Also look at whether a nurse is administering all doses or is the patient being taught (for home care)... then in most cases a flow regulator is most prudent. But if I am doing the administration and sitting right there I would feel comfortable giving Remicade etc gravity... and our policies give us that latitude.